Placental programming, perinatal inflammation, and neurodevelopment impairment among those born extremely preterm
نویسندگان
چکیده
منابع مشابه
Placental CpG methylation of infants born extremely preterm predicts cognitive impairment later in life
BACKGROUND The placenta is the central regulator of maternal and fetal interactions. Perturbations of placental structure and function have been associated with adverse neurodevelopmental outcomes later in life. Placental CpG methylation represents an epigenetic modification with the potential to impact placental function, fetal development and child health later in life. STUDY DESIGN Genome-...
متن کاملSelf-regulation in Children Born Extremely Preterm
Survival rates are increasing for children born extremely preterm, yet despite the majority of these children having IQ scores within the average range, 50-70% of these children have later school difficulties. This paper reviews factors associated with academic difficulties in these children, emphasizing the contributions of executive functions (EF) and self-regulation. The roles of EF are exam...
متن کاملPERINATAL BRAIN DAMAGE IN VERY PRETERM INFANTS Prenatal inflammation and neurologic outcome in children born term and preterm Tiivistelmä suomeksi
Despite improvements in periand neonatal care and an increase in the overall survival of very preterm infants, the incidence of neurologic sequelae has remained high. The pathogenesis of many brain imaging findings, such as white matter damage, WMD, is poorly understood. The factors predisposing to brain damage differ between term and preterm infants. More detailed information is needed of how ...
متن کاملPulmonary gas transfer in children and adolescents born extremely preterm.
In extremely preterm-born infants, gas exchange takes place in developmentally fetal lungs, disturbing normal acinar growth and differentiation, potentially with long term negative consequences for lung function. The aim was to compare alveolar function in children and adolescents born extremely preterm and at term by measuring diffusing capacity of the lung for carbon monoxide (DLCO). Since th...
متن کاملVentilatory Efficiency in Children and Adolescents Born Extremely Preterm
Purpose: Children and adolescents born extremely preterm (EP) have lower dynamic lung volumes and gas transfer capacity than subjects born at term. Most studies also report lower aerobic capacity. We hypothesized that ventilatory efficiency was poorer and that breathing patterns differed in EP-born compared to term-born individuals. Methods: Two area-based cohorts of participants born with gest...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 2020
ISSN: 0031-3998,1530-0447
DOI: 10.1038/s41390-020-01236-1